Tag Archives: neurodegeneration

Amyloid β-protein and Synaptophysin

Amyloid β-peptide is normally produced in the brain from the amyloid precursor protein (APP). The amyloid cascade hypothesis of Alzheimer disease says that abnormal accumulation in the brain of amyloid β-peptide (Aβ) causes disruption of synaptic neurotransmission and, eventually, the death of neurons … Continue reading

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Regulation of Monoamine Oxidase in Parkinson Disease

In an earlier blog post I linked to an article about the potential role of dopamine metabolism and oxidative stress in Parkinson disease. Now the research group of Jian Feng reports that the protein Parkin regulates the expression of monoamine … Continue reading

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Vesicular monoamine transporter

The previous blog post mentioned the idea that dopamine (DA) can regulate the extent of gap junction coupling between neurons. In Parkinson disease there is loss of dopamine-producing neurons (neurodegeneration) and one pharmacological approach to improving motor control is to … Continue reading

Posted in Diseases, dyskinesia, Huntington disease, L-DOPA, membrane transport, Parkinson disease, pharmacology, tetrabenazine | Tagged , , , , , | 1 Comment

What causes neuronal cell death in Parkinson disease?

The leucine-rich repeat kinase 2 (LRRK2) gene codes for a protein kinase that has the ability to function in a dominant way to cause neurodegeneration. Mutations in the human LRRK2 gene can cause Parkinson disease. The LRRK2 protein and it … Continue reading

Posted in Diseases, Parkinson disease | Tagged , , , , , | 1 Comment