Category Archives: signal transduction

Synapse Disruption & Alzheimer Disease

Brain dysfunction in Alzheimer Disease (AD) has been associated with abnormal production of the amyloid-β (Aβ) peptide. Aβ is generated by proteolytic processing from the amyloid precursor protein (APP). APP is a member of the APP gene family which codes … Continue reading

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Protein Kinase M and LTP

My previous blog post was also about LTP: long-term potentiation of synapses. Here, the topic is what has been called late-LTP (L-LTP), a strengthening of synapses that can last for months in the hippocampus of laboratory animals. Molecular and cellular … Continue reading

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Presynaptic Endocannabinoid-initiated LTP

“LTP” is long-term potentiation, a type of synaptic plasticity found in the hippocampus that is involved in episodic memory storage. A recent research article reports on the mechanism by which endocannabinoid signaling affects the induction of hippocampal long-term potentiation (LTP). … Continue reading

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Circadian Pacemaker

In my previous blog post, I mentioned that the GHSR1 ghrelin receptor has a high level of activity independent of ghrelin binding.  Recently, an “orphan” G Protein-coupled Receptor (GPCR) (Gpr176) has been implicated in the function of the circadian pacemaker of … Continue reading

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Ghrelin

Ghrelin is a vertebrate peptide hormone that has been most heavily studied for its role as a signalling molecule that is made in the gastrointestinal tract and which can modulate the behavior of ghrelin receptors on neurons, both in the … Continue reading

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Tissue factor

tissue factor Tissue factor, also known as blood coagulation factor III, is a transmembrane protein  that is important for blood clotting (1). Tissue factor can bind coagulation factor VII, resulting in the activation of its protease activity and leading to fibrin clot … Continue reading

Posted in hemostasis, hypercoagulation, oral contraceptives, pharmacology, protease-activated receptor, proteolysis | Tagged , , , | 1 Comment

Entry into the age of genes

This blog post is about trying to understand what goes wrong in Alzheimer disease. I want to start the story 100 years ago… In 1911 Thomas Morgan began the task of locating genes along the length of chromosomes. 100 years later, … Continue reading

Posted in Alzheimer disease, history, lithium, pharmacology, rosiglitazone, signal transduction, Wnt pathway | Tagged , , , , | 1 Comment