Category Archives: L-DOPA

Regulation of Monoamine Oxidase in Parkinson Disease

In an earlier blog post I linked to an article about the potential role of dopamine metabolism and oxidative stress in Parkinson disease. Now the research group of Jian Feng reports that the protein Parkin regulates the expression of monoamine … Continue reading

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Functions of dopamine in the basal ganglia

Parkinson disease can be caused by loss of dapaminergic neurons in the substantia nigra. There are two major populations of neurons in the striatum that respond to dopamine. Their roles in movement disorders are the subjuct of ongoing research. I … Continue reading

Posted in dyskinesia, Huntington disease, L-DOPA, Parkinson disease | Tagged , , , | 1 Comment

Journal Club

I’m trying to establish a more formal system for a “journal club”, but for now we can use this blog. [Update, Spring 2012, see this journal club page.] This blog post starts the “journal club”. “Journal club” means that participants will each … Continue reading

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Vesicular monoamine transporter

The previous blog post mentioned the idea that dopamine (DA) can regulate the extent of gap junction coupling between neurons. In Parkinson disease there is loss of dopamine-producing neurons (neurodegeneration) and one pharmacological approach to improving motor control is to … Continue reading

Posted in Diseases, dyskinesia, Huntington disease, L-DOPA, membrane transport, Parkinson disease, pharmacology, tetrabenazine | Tagged , , , , , | 1 Comment