Category Archives: Parkinson disease

Regulation of Monoamine Oxidase in Parkinson Disease

In an earlier blog post I linked to an article about the potential role of dopamine metabolism and oxidative stress in Parkinson disease. Now the research group of Jian Feng reports that the protein Parkin regulates the expression of monoamine … Continue reading

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Functions of dopamine in the basal ganglia

Parkinson disease can be caused by loss of dapaminergic neurons in the substantia nigra. There are two major populations of neurons in the striatum that respond to dopamine. Their roles in movement disorders are the subjuct of ongoing research. I … Continue reading

Posted in dyskinesia, Huntington disease, L-DOPA, Parkinson disease | Tagged , , , | 1 Comment

Striatal direct and indirect pathways

This blog post is about the idea that there are two populations of neurons in the striatum that have essentially opposite effects on the control of movement. Set science free. There is a trend towards having more of the biomedical … Continue reading

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Vesicular monoamine transporter

The previous blog post mentioned the idea that dopamine (DA) can regulate the extent of gap junction coupling between neurons. In Parkinson disease there is loss of dopamine-producing neurons (neurodegeneration) and one pharmacological approach to improving motor control is to … Continue reading

Posted in Diseases, dyskinesia, Huntington disease, L-DOPA, membrane transport, Parkinson disease, pharmacology, tetrabenazine | Tagged , , , , , | 1 Comment

Gap junctions in the brain

Most connections between neurons are chemical synapses, but there are also gap junctions in the brain. Gap junctions between neurons have been particularly well studied for inhibitory interneurons. For example, the diagram here (to the right) shows gap junctions between … Continue reading

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What causes neuronal cell death in Parkinson disease?

The leucine-rich repeat kinase 2 (LRRK2) gene codes for a protein kinase that has the ability to function in a dominant way to cause neurodegeneration. Mutations in the human LRRK2 gene can cause Parkinson disease. The LRRK2 protein and it … Continue reading

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