Category Archives: Huntington disease

Functions of dopamine in the basal ganglia

Parkinson disease can be caused by loss of dapaminergic neurons in the substantia nigra. There are two major populations of neurons in the striatum that respond to dopamine. Their roles in movement disorders are the subjuct of ongoing research. I … Continue reading

Posted in dyskinesia, Huntington disease, L-DOPA, Parkinson disease | Tagged , , , | 1 Comment

Striatal direct and indirect pathways

This blog post is about the idea that there are two populations of neurons in the striatum that have essentially opposite effects on the control of movement. Set science free. There is a trend towards having more of the biomedical … Continue reading

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Vesicular monoamine transporter

The previous blog post mentioned the idea that dopamine (DA) can regulate the extent of gap junction coupling between neurons. In Parkinson disease there is loss of dopamine-producing neurons (neurodegeneration) and one pharmacological approach to improving motor control is to … Continue reading

Posted in Diseases, dyskinesia, Huntington disease, L-DOPA, membrane transport, Parkinson disease, pharmacology, tetrabenazine | Tagged , , , , , | 1 Comment