Category Archives: Alzheimer disease

Synapse Disruption & Alzheimer Disease

Brain dysfunction in Alzheimer Disease (AD) has been associated with abnormal production of the amyloid-β (Aβ) peptide. Aβ is generated by proteolytic processing from the amyloid precursor protein (APP). APP is a member of the APP gene family which codes … Continue reading

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Amyloid β-protein and Synaptophysin

Amyloid β-peptide is normally produced in the brain from the amyloid precursor protein (APP). The amyloid cascade hypothesis of Alzheimer disease says that abnormal accumulation in the brain of amyloid β-peptide (Aβ) causes disruption of synaptic neurotransmission and, eventually, the death of neurons … Continue reading

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Entry into the age of genes

This blog post is about trying to understand what goes wrong in Alzheimer disease. I want to start the story 100 years ago… In 1911 Thomas Morgan began the task of locating genes along the length of chromosomes. 100 years later, … Continue reading

Posted in Alzheimer disease, history, lithium, pharmacology, rosiglitazone, signal transduction, Wnt pathway | Tagged , , , , | 1 Comment